Craig and tweek are gay

Yes. Tweek and Craig are gay. This is not only a plot point in The Fractured But Whole but, more importantly, in the audio commentary on S21E02, Put It Down, Parker and Stone categorically confirm the boys are in a genuine relationship, not for the sake of the town but because they like-like each other a lot-lot.

Craig convinces Tweek to announce that they are gay and then stage a fake breakup in order to put the matter to rest. Initially reluctant, Tweek gets carried away with the performance, portraying Craig as a manipulative cheater and himself as the wronged party.